Fungal iron homeostasis with a focus on Aspergillus fumigatus.
Identifieur interne : 000076 ( Main/Exploration ); précédent : 000075; suivant : 000077Fungal iron homeostasis with a focus on Aspergillus fumigatus.
Auteurs : Matthias Misslinger [Autriche] ; Peter Hortschansky [Allemagne] ; Axel A. Brakhage [Allemagne] ; Hubertus Haas [Autriche]Source :
- Biochimica et biophysica acta. Molecular cell research [ 1879-2596 ] ; 2020.
Abstract
To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization to ensure sufficient supply and to avoid toxic excess of this essential trace element. As pathogens usually encounter iron limitation in the host niche, this metal plays a particular role during virulence. Siderophores are iron-chelators synthesized by most, but not all fungal species to sequester iron extra- and intracellularly. In recent years, the facultative human pathogen Aspergillus fumigatus has become a model for fungal iron homeostasis of siderophore-producing fungal species. This article summarizes the knowledge on fungal iron homeostasis and its links to virulence with a focus on A. fumigatus. It covers mechanisms for iron acquisition, storage, and detoxification, as well as the modes of transcriptional iron regulation and iron sensing in A. fumigatus in comparison to other fungal species. Moreover, potential translational applications of the peculiarities of fungal iron metabolism for treatment and diagnosis of fungal infections is addressed.
DOI: 10.1016/j.bbamcr.2020.118885
PubMed: 33045305
Affiliations:
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Brakhage</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany; Department Microbiology and Molecular Biology, Institute of Microbiology, Friedrich Schiller University Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany; Department Microbiology and Molecular Biology, Institute of Microbiology, Friedrich Schiller University Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Haas, Hubertus" sort="Haas, Hubertus" uniqKey="Haas H" first="Hubertus" last="Haas">Hubertus Haas</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Molecular Biology - Biocenter, Medical University of Innsbruck, Innsbruck, Austria. 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Molecular cell research</Title><ISOAbbreviation>Biochim Biophys Acta Mol Cell Res</ISOAbbreviation></Journal><ArticleTitle>Fungal iron homeostasis with a focus on Aspergillus fumigatus.</ArticleTitle><Pagination><MedlinePgn>118885</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0167-4889(20)30243-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbamcr.2020.118885</ELocationID><Abstract><AbstractText>To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization to ensure sufficient supply and to avoid toxic excess of this essential trace element. As pathogens usually encounter iron limitation in the host niche, this metal plays a particular role during virulence. Siderophores are iron-chelators synthesized by most, but not all fungal species to sequester iron extra- and intracellularly. In recent years, the facultative human pathogen Aspergillus fumigatus has become a model for fungal iron homeostasis of siderophore-producing fungal species. This article summarizes the knowledge on fungal iron homeostasis and its links to virulence with a focus on A. fumigatus. It covers mechanisms for iron acquisition, storage, and detoxification, as well as the modes of transcriptional iron regulation and iron sensing in A. fumigatus in comparison to other fungal species. Moreover, potential translational applications of the peculiarities of fungal iron metabolism for treatment and diagnosis of fungal infections is addressed.</AbstractText><CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Misslinger</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Molecular Biology - Biocenter, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hortschansky</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brakhage</LastName><ForeName>Axel A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany; Department Microbiology and Molecular Biology, Institute of Microbiology, Friedrich Schiller University Jena, Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haas</LastName><ForeName>Hubertus</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Molecular Biology - Biocenter, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: hubertus.haas@i-med.ac.at.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta Mol Cell Res</MedlineTA><NlmUniqueID>101731731</NlmUniqueID><ISSNLinking>0167-4889</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">GATA SreA</Keyword><Keyword MajorTopicYN="N">Glutaredoxin</Keyword><Keyword MajorTopicYN="N">Iron</Keyword><Keyword MajorTopicYN="N">Sensing</Keyword><Keyword MajorTopicYN="N">Siderophore</Keyword><Keyword MajorTopicYN="N">bZIP HapX</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>09</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>12</Day><Hour>20</Hour><Minute>8</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33045305</ArticleId><ArticleId IdType="pii">S0167-4889(20)30243-3</ArticleId><ArticleId IdType="doi">10.1016/j.bbamcr.2020.118885</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Misslinger, Matthias" sort="Misslinger, Matthias" uniqKey="Misslinger M" first="Matthias" last="Misslinger">Matthias Misslinger</name></region><name sortKey="Haas, Hubertus" sort="Haas, Hubertus" uniqKey="Haas H" first="Hubertus" last="Haas">Hubertus Haas</name></country><country name="Allemagne"><noRegion><name sortKey="Hortschansky, Peter" sort="Hortschansky, Peter" uniqKey="Hortschansky P" first="Peter" last="Hortschansky">Peter Hortschansky</name></noRegion><name sortKey="Brakhage, Axel A" sort="Brakhage, Axel A" uniqKey="Brakhage A" first="Axel A" last="Brakhage">Axel A. 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